Search results for "Élongationdes acides gras"

The Elovl5 enzyme in breast cancer : regulation of cancer cell proliferation and metastasis

2021

Breast cancer is the most diagnosed cancer and the leading cause of cancer death in women. The 5-year relative survival rate is less than 30% for metastatic breast cancer and metastases account for more than 75% of breast cancer deaths. Fatty acid metabolism is altered in cancer and contributes to tumor progression and metastasis. Here, we were interested in Elongation of very long chain fatty acids protein 5 (Elovl5) which catalyzes the elongation of long-chain fatty acids. We observed that the tumors from patients with a breast cancer had a lower expression of Elovl5 than paired normal breast tissue. However, low expression of Elovl5 is associated with a worse prognosis in breast cancer p…